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Nonsynonymous, synonymous and nonsense mutations in human cancer-related genes undergo stronger purifying selections than expectation

Abstract Background Nonsynonymous mutations change the protein sequences and are frequently subjected to natural selection. The same goes for nonsense mutations that introduce pre-mature stop codons into CDSs (coding sequences). Synonymous mutations, however, are intuitively thought to be functional...

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Principais autores: Duan Chu, Lai Wei
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-04-01
Serier:BMC Cancer
Fag:
Mutation
Cancer-related genes
Coding region
Codon usage bias (CUB)
Natural selection
Online adgang:http://link.springer.com/article/10.1186/s12885-019-5572-x
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