Improved inference of site-specific positive selection under a generalized parametric codon model when there are multinucleotide mutations and multiple nonsynonymous rates

Abstract Background An excess of nonsynonymous substitutions, over neutrality, is considered evidence of positive Darwinian selection. Inference for proteins often relies on estimation of the nonsynonymous to synonymous ratio (ω = d N/d S) within a codon model. However, to ease computational difficu...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Katherine A. Dunn, Toby Kenney, Hong Gu, Joseph P. Bielawski
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	BMC 2019-01-01
سلاسل:	BMC Evolutionary Biology
الموضوعات:	Codon model Positive selection Protein evolution Multiple nucleotide mutations Multiple nonsynonymous rates M-series models
الوصول للمادة أونلاين:	http://link.springer.com/article/10.1186/s12862-018-1326-7
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!