Synthesis and Evaluation of Artificial Nucleic Acid Bearing an Oxanorbornane Scaffold

Natural oligonucleotides have many rotatable single bonds, and thus their structures are inherently flexible. Structural flexibility leads to an entropic loss when unwound oligonucleotides form a duplex with single-stranded DNA or RNA. An effective approach to reduce such entropic loss in the duplex...

Полное описание

Библиографические подробности

Главные авторы:	Hibiki Komine, Shohei Mori, Kunihiko Morihiro, Kenta Ishida, Takumi Okuda, Yuuya Kasahara, Hiroshi Aoyama, Takao Yamaguchi, Satoshi Obika
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2020-04-01
Серии:	Molecules
Предметы:	modified nucleic acid modified oligonucleotide oxanorbornane conformational restriction entropy duplex-forming ability
Online-ссылка:	https://www.mdpi.com/1420-3049/25/7/1732
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