Synthesis and Evaluation of Artificial Nucleic Acid Bearing an Oxanorbornane Scaffold

Natural oligonucleotides have many rotatable single bonds, and thus their structures are inherently flexible. Structural flexibility leads to an entropic loss when unwound oligonucleotides form a duplex with single-stranded DNA or RNA. An effective approach to reduce such entropic loss in the duplex...

全面介紹

書目詳細資料

Principais autores:	Hibiki Komine, Shohei Mori, Kunihiko Morihiro, Kenta Ishida, Takumi Okuda, Yuuya Kasahara, Hiroshi Aoyama, Takao Yamaguchi, Satoshi Obika
格式:	Artigo
語言:	Inglês
出版:	MDPI AG 2020-04-01
叢編:	Molecules
主題:	modified nucleic acid modified oligonucleotide oxanorbornane conformational restriction entropy duplex-forming ability
在線閱讀:	https://www.mdpi.com/1420-3049/25/7/1732
標簽:	添加標簽 沒有標簽, 成為第一個標記此記錄!