Synthesis and Evaluation of Artificial Nucleic Acid Bearing an Oxanorbornane Scaffold

Natural oligonucleotides have many rotatable single bonds, and thus their structures are inherently flexible. Structural flexibility leads to an entropic loss when unwound oligonucleotides form a duplex with single-stranded DNA or RNA. An effective approach to reduce such entropic loss in the duplex...

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Autors principals:	Hibiki Komine, Shohei Mori, Kunihiko Morihiro, Kenta Ishida, Takumi Okuda, Yuuya Kasahara, Hiroshi Aoyama, Takao Yamaguchi, Satoshi Obika
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2020-04-01
Col·lecció:	Molecules
Matèries:	modified nucleic acid modified oligonucleotide oxanorbornane conformational restriction entropy duplex-forming ability
Accés en línia:	https://www.mdpi.com/1420-3049/25/7/1732
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