Synthesis and Evaluation of Artificial Nucleic Acid Bearing an Oxanorbornane Scaffold

Natural oligonucleotides have many rotatable single bonds, and thus their structures are inherently flexible. Structural flexibility leads to an entropic loss when unwound oligonucleotides form a duplex with single-stranded DNA or RNA. An effective approach to reduce such entropic loss in the duplex...

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Principais autores:	Hibiki Komine, Shohei Mori, Kunihiko Morihiro, Kenta Ishida, Takumi Okuda, Yuuya Kasahara, Hiroshi Aoyama, Takao Yamaguchi, Satoshi Obika
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2020-04-01
Series:	Molecules
Assuntos:	modified nucleic acid modified oligonucleotide oxanorbornane conformational restriction entropy duplex-forming ability
Acceso en liña:	https://www.mdpi.com/1420-3049/25/7/1732
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