Interferon hyperactivity impairs cardiogenesis in Down syndrome via downregulation of canonical Wnt signaling

Summary: Congenital heart defects (CHDs) are frequent in children with Down syndrome (DS), caused by trisomy of chromosome 21. However, the underlying mechanisms are poorly understood. Here, using a human-induced pluripotent stem cell (iPSC)-based model and the Dp(16)1Yey/+ (Dp16) mouse model of DS,...

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Autori principali:	Congwu Chi, Walter E. Knight, Andrew S. Riching, Zhen Zhang, Roubina Tatavosian, Yonghua Zhuang, Radu Moldovan, Angela L. Rachubinski, Dexiang Gao, Hongyan Xu, Joaquin M. Espinosa, Kunhua Song
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2023-07-01
Serie:	iScience
Soggetti:	Cell biology Stem cells research Developmental biology Transcriptomics
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2589004223010891
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