Delactylation of viral proteins by SIRT1 suppresses influenza A virus replication

ABSTRACT Lactylation, a protein post-translational modification driven by lactate, plays crucial roles in various physiological and pathological processes. However, the function and underlying mechanisms of lactylation in infection and pathogenesis of influenza A virus (IAV) remain poorly understood...

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Principais autores:	Dongdong Chen, Gejie Zhao, Jia Zhou, Peng Sun, Shutong He, Changjie Lv, Yuhai Chen, Shouhai Zhu, Ming Gao, Guijie Guo
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology 2026-04-01
Series:	mBio
Assuntos:	influenza A virus SIRT1 vRNP lactylation virus replication
Acceso en liña:	https://journals.asm.org/doi/10.1128/mbio.02489-25
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