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Quantitative Analysis of Daporinad (FK866) and Its In Vitro and In Vivo Metabolite Identification Using Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry

Daporinad (FK866) is one of the highly specific inhibitors of nicotinamide phosphoribosyl transferase (NAMPT) and known to have its unique mechanism of action that induces the tumor cell apoptosis. In this study, a simple and sensitive liquid chromatography–quadrupole-time-of-flight–mass spectrometr...

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Главные авторы: Minjae Park, Byeong Ill Lee, Jangmi Choi, Yuri Park, Seo-Jin Park, Jeong-Hyeon Lim, Jiyu Lee, Young G. Shin
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI AG 2022-03-01
Серии:Molecules
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Online-ссылка:https://www.mdpi.com/1420-3049/27/6/2011
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