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Quantitative Analysis of Daporinad (FK866) and Its In Vitro and In Vivo Metabolite Identification Using Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry

Daporinad (FK866) is one of the highly specific inhibitors of nicotinamide phosphoribosyl transferase (NAMPT) and known to have its unique mechanism of action that induces the tumor cell apoptosis. In this study, a simple and sensitive liquid chromatography–quadrupole-time-of-flight–mass spectrometr...

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Main Authors: Minjae Park, Byeong Ill Lee, Jangmi Choi, Yuri Park, Seo-Jin Park, Jeong-Hyeon Lim, Jiyu Lee, Young G. Shin
Format: Artigo
Language:Inglês
Published: MDPI AG 2022-03-01
Series:Molecules
Subjects:
Daporinad (FK866)
NAMPT inhibitor
LC-qTOF-MS
qualification
pharmacokinetic
metabolism
Online Access:https://www.mdpi.com/1420-3049/27/6/2011
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