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Delactylation of viral proteins by SIRT1 suppresses influenza A virus replication

ABSTRACT Lactylation, a protein post-translational modification driven by lactate, plays crucial roles in various physiological and pathological processes. However, the function and underlying mechanisms of lactylation in infection and pathogenesis of influenza A virus (IAV) remain poorly understood...

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Principais autores: Dongdong Chen, Gejie Zhao, Jia Zhou, Peng Sun, Shutong He, Changjie Lv, Yuhai Chen, Shouhai Zhu, Ming Gao, Guijie Guo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2026-04-01
Serier:mBio
Fag:
influenza A virus
SIRT1
vRNP
lactylation
virus replication
Online adgang:https://journals.asm.org/doi/10.1128/mbio.02489-25
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