MicroRNAs located in the Hox gene clusters are implicated in huntington's disease pathogenesis.

Transcriptional dysregulation has long been recognized as central to the pathogenesis of Huntington's disease (HD). MicroRNAs (miRNAs) represent a major system of post-transcriptional regulation, by either preventing translational initiation or by targeting transcripts for storage or for degradation...

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書誌詳細

主要な著者:	Andrew G Hoss, Vinay K Kartha, Xianjun Dong, Jeanne C Latourelle, Alexandra Dumitriu, Tiffany C Hadzi, Marcy E Macdonald, James F Gusella, Schahram Akbarian, Jiang-Fan Chen, Zhiping Weng, Richard H Myers
フォーマット:	Artigo
言語:	Inglês
出版事項:	Public Library of Science (PLoS) 2014-02-01
シリーズ:	PLoS Genetics
オンライン･アクセス:	https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1004188&type=printable
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