Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs

Abstract Mitochondrial diseases are maternally inherited heterogeneous disorders that are primarily caused by mitochondrial DNA (mtDNA) mutations. Depending on the ratio of mutant to wild-type mtDNA, known as heteroplasmy, mitochondrial defects can result in a wide spectrum of clinical manifestation...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Yi Yang, Han Wu, Xiangjin Kang, Yanhui Liang, Ting Lan, Tianjie Li, Tao Tan, Jiangyun Peng, Quanjun Zhang, Geng An, Yali Liu, Qian Yu, Zhenglai Ma, Ying Lian, Boon Seng Soh, Qingfeng Chen, Ping Liu, Yaoyong Chen, Xiaofang Sun, Rong Li, Xiumei Zhen, Yang Yu, Xiaoping Li, Yong Fan
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Oxford University Press 2018-01-01
Edice:	Protein & Cell
Témata:	mitochondria iPSCs TALEN MELAS
On-line přístup:	http://link.springer.com/article/10.1007/s13238-017-0499-y
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!