Mosaic AAV mediates efficient transduction across the central and peripheral nervous systems
Abstract Adeno-associated virus (AAV) is a promising vector for neurological gene therapy, yet engineered serotypes are restricted to targeting either the central or peripheral nervous system (CNS or PNS). To overcome this limitation, we generated AAV with mosaic capsid, AAV-PHP.(S + eB), by co-pack...
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| Principais autores: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BMC
2025-12-01
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| Serier: | Molecular Brain |
| Fag: | |
| Online adgang: | https://doi.org/10.1186/s13041-025-01270-2 |
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