Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs

Abstract Mitochondrial diseases are maternally inherited heterogeneous disorders that are primarily caused by mitochondrial DNA (mtDNA) mutations. Depending on the ratio of mutant to wild-type mtDNA, known as heteroplasmy, mitochondrial defects can result in a wide spectrum of clinical manifestation...

Full beskrivning

Bibliografiska uppgifter

Huvudupphov:	Yi Yang, Han Wu, Xiangjin Kang, Yanhui Liang, Ting Lan, Tianjie Li, Tao Tan, Jiangyun Peng, Quanjun Zhang, Geng An, Yali Liu, Qian Yu, Zhenglai Ma, Ying Lian, Boon Seng Soh, Qingfeng Chen, Ping Liu, Yaoyong Chen, Xiaofang Sun, Rong Li, Xiumei Zhen, Yang Yu, Xiaoping Li, Yong Fan
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Oxford University Press 2018-01-01
Serie:	Protein & Cell
Ämnen:	mitochondria iPSCs TALEN MELAS
Länkar:	http://link.springer.com/article/10.1007/s13238-017-0499-y
Taggar:	Lägg till en tagg Inga taggar, Lägg till första taggen!