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In silico design of novel pyridazine derivatives as balanced multifunctional agents against Alzheimer’s disease

Abstract Alzheimer’s disease (AD) necessitates innovative therapeutic approaches that target its multifaceted pathology. This study investigates a series of 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2H)-one derivatives as potential multi-target ligands for AD, aiming to simultaneously inhibit acet...

Täydet tiedot

Tallennettuna:
Päätekijät: Mourad Aloui, Mohamed El fadili, Somdutt Mujwar, Mohammed Er-rajy, Hatem A. Abuelizz, Sara Er-rahmani, Sara Zarougui, Elhalaoui Menana
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Portfolio 2025-05-01
Sarja:Scientific Reports
Aiheet:
QSAR
Pyridazine
Molecular docking
Molecular dynamic
ADMET propriety
Alzheimer’s disease
Linkit:https://doi.org/10.1038/s41598-025-98182-x
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