Design and evaluation of novel triazole derivatives as potential anti-gout inhibitors: a comprehensive molecular modeling study

IntroductionGout is the most common inflammatory arthritis, characterized by hyperuricemia, tophus formation, joint disease, and kidney stones. Uric acid, the final byproduct of purine catabolism, is eliminated via the kidneys and digestive system. Xanthine oxidase (XO) catalyzes the conversion of h...

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Egile Nagusiak:	Mohammed Er-rajy, Mohamed El fadili, Sara Zarougui, Somdutt Mujwar, Mourad Aloui, Mohammed Zerrouk, Belkheir Hammouti, Larbi Rhazi, Rachid Sabbahi, Mohammed M. Alanazi, Khalil Azzaoui, Rachid Salghi, Menana Elhallaoui
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Frontiers Media S.A. 2025-03-01
Saila:	Frontiers in Chemistry
Gaiak:	3D-QSAR anti-gout drugs molecular docking molecular dynamic conception of novel derivatives ADMET proprieties
Sarrera elektronikoa:	https://www.frontiersin.org/articles/10.3389/fchem.2025.1518777/full
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