Design of novel pyrazole and benzofuran-based derivatives as potent acetylcholinesterase inhibitors for Alzheimer’s disease management

IntroductionBeing a complex neurodegenerative disease with many clinical features, Alzheimer’s disease calls for multiple-targeted drugs to treat several aspects of its progression in the human body. The present study sheds light on evaluating and designing novel pyrazole and benzofuran-based deriva...

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Hlavní autoři:	Mohamed El Fadili, Amine Ez-Zoubi, Mourad Aloui, Somdutt Mujwar, Hatem A. Abuelizz, Menana Elhalaoui, Adnan Amin
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-05-01
Edice:	Frontiers in Chemistry
Témata:	Alzheimer’s disease AChE 3D-QSAR DFT molecular docking molecular dynamics
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fchem.2025.1614462/full
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