Deubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke

Abstract As a common and severe cerebrovascular disease, ischemic stroke casts a significant shadow over global health. Unfortunately, the mechanisms regulating neuronal death in the affected areas remain largely unclear. Here, we found that deletion of the deubiquitinating enzyme Otubain-2 (OTUB2)...

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Autors principals:	Fuqi Mei, Deyu Deng, Zijun Cao, Liyan Lou, Kangmin Chen, Minjie Hu, Zhenhu Zhu, Jiangyun Shen, Jianzhao Zhang, Jie Liang, Jingyong Huang, Min Bao, Ari Waisman, Xu Wang
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer Nature 2025-02-01
Col·lecció:	EMBO Molecular Medicine
Matèries:	Ischemic Stroke Necroptosis Ubiquitination OTUB2 RIPK3
Accés en línia:	https://doi.org/10.1038/s44321-025-00206-6
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