Deubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke

Abstract As a common and severe cerebrovascular disease, ischemic stroke casts a significant shadow over global health. Unfortunately, the mechanisms regulating neuronal death in the affected areas remain largely unclear. Here, we found that deletion of the deubiquitinating enzyme Otubain-2 (OTUB2)...

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Главные авторы:	Fuqi Mei, Deyu Deng, Zijun Cao, Liyan Lou, Kangmin Chen, Minjie Hu, Zhenhu Zhu, Jiangyun Shen, Jianzhao Zhang, Jie Liang, Jingyong Huang, Min Bao, Ari Waisman, Xu Wang
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Springer Nature 2025-02-01
Серии:	EMBO Molecular Medicine
Предметы:	Ischemic Stroke Necroptosis Ubiquitination OTUB2 RIPK3
Online-ссылка:	https://doi.org/10.1038/s44321-025-00206-6
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