APP dyshomeostasis in the pathogenesis of Alzheimer’s disease: implications for current drug targets

Abstract The Amyloid precursor protein (APP) is a transmembrane glycoprotein from which amyloid-β (Aβ) peptides are generated after proteolytic cleavage. Aβ peptides are the main constituent of amyloid plaques in Alzheimer’s Disease (AD). The physiological functions of APP in the human adult brain a...

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Hlavní autoři:	Sònia Sirisi, Érika Sánchez-Aced, Olivia Belbin, Alberto Lleó
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-06-01
Edice:	Alzheimer’s Research & Therapy
Témata:	Alzheimer’s disease Down syndrome APP Therapeutic targets Drug
On-line přístup:	https://doi.org/10.1186/s13195-024-01504-w
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