APP dyshomeostasis in the pathogenesis of Alzheimer’s disease: implications for current drug targets
Abstract The Amyloid precursor protein (APP) is a transmembrane glycoprotein from which amyloid-β (Aβ) peptides are generated after proteolytic cleavage. Aβ peptides are the main constituent of amyloid plaques in Alzheimer’s Disease (AD). The physiological functions of APP in the human adult brain a...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BMC
2024-06-01
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| Serie: | Alzheimer’s Research & Therapy |
| Soggetti: | |
| Accesso online: | https://doi.org/10.1186/s13195-024-01504-w |
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