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Estradiol ameliorates AD pathology and cognitive deficits by SORLA-mediated APP endosomal trafficking

Abstract Alzheimer’s disease (AD) shows a notable female bias in both prevalence and severity. This bias is closely linked to declining estradiol levels during menopause. Our study demonstrated that estradiol can inhibit the accelerated progression of AD caused by ovariectomy (OVX) in female APP/PS1...

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Principais autores: Fengting Cao, Jinxi Liu, Hongchun Zuo, Xulian Lin, Yuhong Su, Chang Wang, Huixian Cui, Juan Du, Yizhou Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-03-01
Colecção:Alzheimer’s Research & Therapy
Assuntos:
Alzheimer’s disease
Estradiol
SORLA
APP
ERα
Endosomal trafficking
Acesso em linha:https://doi.org/10.1186/s13195-026-02027-2
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