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Estradiol ameliorates AD pathology and cognitive deficits by SORLA-mediated APP endosomal trafficking

Abstract Alzheimer’s disease (AD) shows a notable female bias in both prevalence and severity. This bias is closely linked to declining estradiol levels during menopause. Our study demonstrated that estradiol can inhibit the accelerated progression of AD caused by ovariectomy (OVX) in female APP/PS1...

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Principais autores: Fengting Cao, Jinxi Liu, Hongchun Zuo, Xulian Lin, Yuhong Su, Chang Wang, Huixian Cui, Juan Du, Yizhou Zhang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-03-01
Serier:Alzheimer’s Research & Therapy
Fag:
Alzheimer’s disease
Estradiol
SORLA
APP
ERα
Endosomal trafficking
Online adgang:https://doi.org/10.1186/s13195-026-02027-2
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