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APP dyshomeostasis in the pathogenesis of Alzheimer’s disease: implications for current drug targets

Abstract The Amyloid precursor protein (APP) is a transmembrane glycoprotein from which amyloid-β (Aβ) peptides are generated after proteolytic cleavage. Aβ peptides are the main constituent of amyloid plaques in Alzheimer’s Disease (AD). The physiological functions of APP in the human adult brain a...

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Principais autores: Sònia Sirisi, Érika Sánchez-Aced, Olivia Belbin, Alberto Lleó
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-06-01
Serier:Alzheimer’s Research & Therapy
Fag:
Alzheimer’s disease
Down syndrome
APP
Therapeutic targets
Drug
Online adgang:https://doi.org/10.1186/s13195-024-01504-w
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