Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation

Abstract Background Microglia function is essential to maintain the brain homeostasis. Evidence shows that aged microglia are primed and show exaggerated response to acute inflammatory challenge. Systemic inflammation signals to the brain inducing changes that impact cognitive function. However, the...

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Auteurs principaux:	Joana Costa d’Avila, Luciana Domett Siqueira, Aurélien Mazeraud, Estefania Pereira Azevedo, Debora Foguel, Hugo Caire Castro-Faria-Neto, Tarek Sharshar, Fabrice Chrétien, Fernando Augusto Bozza
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2018-01-01
Collection:	Journal of Neuroinflammation
Sujets:	Aging Microglia Nox2 Sepsis Brain Cytokines
Accès en ligne:	http://link.springer.com/article/10.1186/s12974-018-1059-y
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