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Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation

Abstract Background Microglia function is essential to maintain the brain homeostasis. Evidence shows that aged microglia are primed and show exaggerated response to acute inflammatory challenge. Systemic inflammation signals to the brain inducing changes that impact cognitive function. However, the...

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Principais autores: Joana Costa d’Avila, Luciana Domett Siqueira, Aurélien Mazeraud, Estefania Pereira Azevedo, Debora Foguel, Hugo Caire Castro-Faria-Neto, Tarek Sharshar, Fabrice Chrétien, Fernando Augusto Bozza
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-01-01
coleção:Journal of Neuroinflammation
Assuntos:
Aging
Microglia
Nox2
Sepsis
Brain
Cytokines
Acesso em linha:http://link.springer.com/article/10.1186/s12974-018-1059-y
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