GLUT1-driven glycolytic reprogramming in microglia promotes neuroinflammation and cognitive deficits in sepsis-associated encephalopathy

Background: Sepsis-associated encephalopathy (SAE) is a severe neurological complication driven by microglial neuroinflammation. Proinflammatory microglial activation requires glycolytic reprogramming, but whether GLUT1 governs this process in SAE remains unclear. Methods: In vitro, LPS-stimulated B...

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Detalhes bibliográficos

Principais autores:	Hui Guo, Hongling Li, Hu Han, Yubo Wei, Shuaikang Liu, Keke Han, Hexin Zhai, Shimin Dong
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-09-01
coleção:	Brain Research Bulletin
Assuntos:	Sepsis-associated encephalopathy Microglia GLUT1 Glycolysis Neuroinflammation
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S036192302600314X
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