Phase I dose-escalation oncology trials with sequential multiple schedules

Abstract Background Conventional methods for phase I dose-escalation trials in oncology are based on a single treatment schedule only. More recently, however, multiple schedules are more frequently investigated in the same trial. Methods Here, we consider sequential phase I trials, where the trial p...

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Principais autores:	Burak Kürsad Günhan, Sebastian Weber, Abdelkader Seroutou, Tim Friede
格式:	Artigo
语言:	Inglês
出版:	BMC 2021-04-01
丛编:	BMC Medical Research Methodology
主题:	Phase I dose-escalation trials Multiple treatment schedules PK models Bayesian statistics
在线阅读:	https://doi.org/10.1186/s12874-021-01218-9
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