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What does a modified-Fibonacci dose-escalation actually correspond to?

<p>Abstract</p> <p>Background</p> <p>In most phase I oncology trials, it is often stated that the dose increments follow a “modified-Fibonacci sequence”. This term, however, is vague.</p> <p>Methods</p> <p>To better characterize this sequence, we reviewed 81 phase I trials based on this concept.</p>...

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Principais autores: Penel Nicolas, Kramar Andrew
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2012-07-01
Serier:BMC Medical Research Methodology
Fag:
Dose escalation
Dose increments
Fibonacci sequence
Phase I trials
Methodology
Online adgang:http://www.biomedcentral.com/1471-2288/12/103
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