क्यूआर कोड

How to design a dose-finding study using the continual reassessment method

Abstract Introduction The continual reassessment method (CRM) is a model-based design for phase I trials, which aims to find the maximum tolerated dose (MTD) of a new therapy. The CRM has been shown to be more accurate in targeting the MTD than traditional rule-based approaches such as the 3 + 3 des...

पूर्ण विवरण

में बचाया:
मुख्य लेखकों: Graham M. Wheeler, Adrian P. Mander, Alun Bedding, Kristian Brock, Victoria Cornelius, Andrew P. Grieve, Thomas Jaki, Sharon B. Love, Lang’o Odondi, Christopher J. Weir, Christina Yap, Simon J. Bond
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: BMC 2019-01-01
श्रृंखला:BMC Medical Research Methodology
विषय:
Adaptive designs
Continual reassessment method
Dose escalation
Dose-finding
Maximum tolerated dose
Phase I trials
ऑनलाइन पहुंच:http://link.springer.com/article/10.1186/s12874-018-0638-z
टैग: टैग जोड़ें
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!

समान संसाधन