How to design a dose-finding study using the continual reassessment method

Abstract Introduction The continual reassessment method (CRM) is a model-based design for phase I trials, which aims to find the maximum tolerated dose (MTD) of a new therapy. The CRM has been shown to be more accurate in targeting the MTD than traditional rule-based approaches such as the 3 + 3 des...

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Autors principals:	Graham M. Wheeler, Adrian P. Mander, Alun Bedding, Kristian Brock, Victoria Cornelius, Andrew P. Grieve, Thomas Jaki, Sharon B. Love, Lang’o Odondi, Christopher J. Weir, Christina Yap, Simon J. Bond
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2019-01-01
Col·lecció:	BMC Medical Research Methodology
Matèries:	Adaptive designs Continual reassessment method Dose escalation Dose-finding Maximum tolerated dose Phase I trials
Accés en línia:	http://link.springer.com/article/10.1186/s12874-018-0638-z
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