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How to design a dose-finding study using the continual reassessment method

Abstract Introduction The continual reassessment method (CRM) is a model-based design for phase I trials, which aims to find the maximum tolerated dose (MTD) of a new therapy. The CRM has been shown to be more accurate in targeting the MTD than traditional rule-based approaches such as the 3 + 3 des...

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Principais autores: Graham M. Wheeler, Adrian P. Mander, Alun Bedding, Kristian Brock, Victoria Cornelius, Andrew P. Grieve, Thomas Jaki, Sharon B. Love, Lang’o Odondi, Christopher J. Weir, Christina Yap, Simon J. Bond
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-01-01
coleção:BMC Medical Research Methodology
Assuntos:
Adaptive designs
Continual reassessment method
Dose escalation
Dose-finding
Maximum tolerated dose
Phase I trials
Acesso em linha:http://link.springer.com/article/10.1186/s12874-018-0638-z
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