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Enhanced human somatic cell reprogramming efficiency by fusion of the MYC transactivation domain and OCT4

The development of human induced pluripotent stem cells (iPSCs) holds great promise for regenerative medicine. However the iPSC induction efficiency is still very low and with lengthy reprogramming process. We utilized the highly potent transactivation domain (TAD) of MYC protein to engineer the hum...

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Principais autores: Ling Wang, Delun Huang, Chang Huang, Yexuan Yin, Kaneha Vali, Ming Zhang, Young Tang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017-12-01
Serier:Stem Cell Research
Fag:
OCT4
MYC
Fusion protein
Reprogramming
Transactivation domain
Induced pluripotent stem cells
Online adgang:http://www.sciencedirect.com/science/article/pii/S1873506117302180
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