Enhanced human somatic cell reprogramming efficiency by fusion of the MYC transactivation domain and OCT4

The development of human induced pluripotent stem cells (iPSCs) holds great promise for regenerative medicine. However the iPSC induction efficiency is still very low and with lengthy reprogramming process. We utilized the highly potent transactivation domain (TAD) of MYC protein to engineer the hum...

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Detalhes bibliográficos

Principais autores:	Ling Wang, Delun Huang, Chang Huang, Yexuan Yin, Kaneha Vali, Ming Zhang, Young Tang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2017-12-01
coleção:	Stem Cell Research
Assuntos:	OCT4 MYC Fusion protein Reprogramming Transactivation domain Induced pluripotent stem cells
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1873506117302180
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