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The Diarylheptanoid Curcumin Induces MYC Inhibition and Cross-Links This Oncoprotein to the Coactivator TRRAP

The c-Myc protein (MYC) is a transcription factor with strong oncogenic potential controlling fundamental cellular processes. In most human tumors, MYC is overexpressed by enhanced transcriptional activation, gene amplification, chromosomal rearrangements, or increased protein stabilization. To phar...

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Principais autores: Alexander Mödlhammer, Sandra Pfurtscheller, Andreas Feichtner, Markus Hartl, Rainer Schneider
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-04-01
Serier:Frontiers in Oncology
Fag:
gene regulation
transcription control
cancer
protein modification
cell transformation
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2021.660481/full
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