The Diarylheptanoid Curcumin Induces MYC Inhibition and Cross-Links This Oncoprotein to the Coactivator TRRAP

The c-Myc protein (MYC) is a transcription factor with strong oncogenic potential controlling fundamental cellular processes. In most human tumors, MYC is overexpressed by enhanced transcriptional activation, gene amplification, chromosomal rearrangements, or increased protein stabilization. To phar...

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Hauptverfasser:	Alexander Mödlhammer, Sandra Pfurtscheller, Andreas Feichtner, Markus Hartl, Rainer Schneider
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2021-04-01
Schriftenreihe:	Frontiers in Oncology
Schlagworte:	gene regulation transcription control cancer protein modification cell transformation
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fonc.2021.660481/full
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