AAV8 locoregional delivery induces long-term expression of an immunogenic transgene in macaques despite persisting local inflammation

Adeno-associated virus (AAV) vectors are considered efficient vectors for gene transfer, as illustrated by recent successful clinical trials targeting retinal or neurodegenerative disorders. However, limitations as host immune responses to AAV capsid or transduction of limited regions must still be...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Gwladys Gernoux, Mickaël Guilbaud, Marie Devaux, Malo Journou, Virginie Pichard, Nicolas Jaulin, Adrien Léger, Johanne Le Duff, Jack-Yves Deschamps, Caroline Le Guiner, Philippe Moullier, Yan Cherel, Oumeya Adjali
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-03-01
coleção:	Molecular Therapy: Methods & Clinical Development
Assuntos:	AAV gene transfer locoregional delivery immune response tolerance regulatory T cell
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2329050121000188
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!