Intra-CSF AAV9 and AAVrh10 Administration in Nonhuman Primates: Promising Routes and Vectors for Which Neurological Diseases?

The identification of the most efficient method for whole central nervous system targeting that is translatable to humans and the safest route of adeno-associated virus (AAV) administration is a major concern for future applications in clinics. Additionally, as many AAV serotypes were identified for...

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Detalhes bibliográficos

Principais autores:	Karim Bey, Johan Deniaud, Laurence Dubreil, Béatrice Joussemet, Joseph Cristini, Carine Ciron, Juliette Hordeaux, Morwenn Le Boulc’h, Kevin Marche, Maud Maquigneau, Michaël Guilbaud, Rosalie Moreau, Thibaut Larcher, Jack-Yves Deschamps, Marion Fusellier, Véronique Blouin, Caroline Sevin, Nathalie Cartier, Oumeya Adjali, Patrick Aubourg, Philippe Moullier, Marie-Anne Colle
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2020-06-01
coleção:	Molecular Therapy: Methods & Clinical Development
Assuntos:	nonhuman primate AAV gene therapy central nervous system intra-CSF intrathecal delivery
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2329050120300619
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