Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α
Golgi disassembly is required for mitosis and occurs by vesicle fusion suppression, although the mechanism is unclear. Here, Chang et al. show, with quantitative analyses and crystallography, that Importin-α regulates this process by blocking GM130-p115 interactions in a Ran pathway-independent way.
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| Principais autores: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Portfolio
2019-09-01
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| Serier: | Nature Communications |
| Online adgang: | https://doi.org/10.1038/s41467-019-12207-4 |
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