Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α

Golgi disassembly is required for mitosis and occurs by vesicle fusion suppression, although the mechanism is unclear. Here, Chang et al. show, with quantitative analyses and crystallography, that Importin-α regulates this process by blocking GM130-p115 interactions in a Ran pathway-independent way.

Dades bibliogràfiques

Autors principals:	Chih-Chia Chang, Ching-Jou Chen, Cédric Grauffel, Yu-Chung Pien, Carmay Lim, Su-Yi Tsai, Kuo-Chiang Hsia
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2019-09-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-019-12207-4
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