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Transcriptional regulatory networks underlying gene expression changes in Huntington's disease

Abstract Transcriptional changes occur presymptomatically and throughout Huntington's disease (HD), motivating the study of transcriptional regulatory networks (TRNs) in HD. We reconstructed a genome‐scale model for the target genes of 718 transcription factors (TFs) in the mouse striatum by integra...

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Principais autores: Seth A Ament, Jocelynn R Pearl, Jeffrey P Cantle, Robert M Bragg, Peter J Skene, Sydney R Coffey, Dani E Bergey, Vanessa C Wheeler, Marcy E MacDonald, Nitin S Baliga, Jim Rosinski, Leroy E Hood, Jeffrey B Carroll, Nathan D Price
Format: Artigo
Sprog:Inglês
Udgivet: Springer Nature 2018-03-01
Serier:Molecular Systems Biology
Fag:
Huntington's disease
SMAD3
transcription factor
transcriptional regulatory networks
Online adgang:https://doi.org/10.15252/msb.20167435
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