Transcriptional regulatory networks underlying gene expression changes in Huntington's disease

Abstract Transcriptional changes occur presymptomatically and throughout Huntington's disease (HD), motivating the study of transcriptional regulatory networks (TRNs) in HD. We reconstructed a genome‐scale model for the target genes of 718 transcription factors (TFs) in the mouse striatum by integra...

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Autores principales:	Seth A Ament, Jocelynn R Pearl, Jeffrey P Cantle, Robert M Bragg, Peter J Skene, Sydney R Coffey, Dani E Bergey, Vanessa C Wheeler, Marcy E MacDonald, Nitin S Baliga, Jim Rosinski, Leroy E Hood, Jeffrey B Carroll, Nathan D Price
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Springer Nature 2018-03-01
Colección:	Molecular Systems Biology
Materias:	Huntington's disease SMAD3 transcription factor transcriptional regulatory networks
Acceso en línea:	https://doi.org/10.15252/msb.20167435
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