T160‐phosphorylated CDK2 defines threshold for HGF‐dependent proliferation in primary hepatocytes

Abstract Liver regeneration is a tightly controlled process mainly achieved by proliferation of usually quiescent hepatocytes. The specific molecular mechanisms ensuring cell division only in response to proliferative signals such as hepatocyte growth factor (HGF) are not fully understood. Here, we...

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Auteurs principaux:	Stephanie Mueller, Jérémy Huard, Katharina Waldow, Xiaoyun Huang, Lorenza A D'Alessandro, Sebastian Bohl, Kathleen Börner, Dirk Grimm, Steffen Klamt, Ursula Klingmüller, Marcel Schilling
Format:	Artigo
Langue:	Inglês
Publié:	Springer Nature 2015-03-01
Collection:	Molecular Systems Biology
Sujets:	G1/S transition hepatocyte proliferation HGF mathematical model threshold
Accès en ligne:	https://doi.org/10.15252/msb.20156032
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