Identification of Novel Compounds That Bind to the HGF β-Chain In Silico, Verification by Molecular Mechanics and Quantum Mechanics, and Validation of Their HGF Inhibitory Activity In Vitro

The development of small-molecule drugs targeting growth factors for cancer therapy remains a significant challenge, with only limited successful cases. We attempted to identify hepatocyte growth factor (HGF) inhibitors as novel anti-cancer small-molecule drugs. To identify compounds that bind to th...

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Manylion Llyfryddiaeth

Prif Awduron:	Ko Suzuki, Keitaro Inoue, Ryota Namiguchi, Seiya Morita, Suzuho Hayakawa, Mikuri Yokota, Katsuya Sakai, Kunio Matsumoto, Shunsuke Aoki
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	MDPI AG 2025-04-01
Cyfres:	Molecules
Pynciau:	hepatocyte growth factor (HGF) SBDS molecular docking MDS fragment molecular orbital Met
Mynediad Ar-lein:	https://www.mdpi.com/1420-3049/30/8/1801
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!