T160‐phosphorylated CDK2 defines threshold for HGF‐dependent proliferation in primary hepatocytes

Abstract Liver regeneration is a tightly controlled process mainly achieved by proliferation of usually quiescent hepatocytes. The specific molecular mechanisms ensuring cell division only in response to proliferative signals such as hepatocyte growth factor (HGF) are not fully understood. Here, we...

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Detalhes bibliográficos

Principais autores:	Stephanie Mueller, Jérémy Huard, Katharina Waldow, Xiaoyun Huang, Lorenza A D'Alessandro, Sebastian Bohl, Kathleen Börner, Dirk Grimm, Steffen Klamt, Ursula Klingmüller, Marcel Schilling
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer Nature 2015-03-01
coleção:	Molecular Systems Biology
Assuntos:	G1/S transition hepatocyte proliferation HGF mathematical model threshold
Acesso em linha:	https://doi.org/10.15252/msb.20156032
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