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Notch-Signaling Deregulation Induces Myeloid-Derived Suppressor Cells in T-Cell Acute Lymphoblastic Leukemia

Notch receptors deeply influence T-cell development and differentiation, and their dysregulation represents a frequent causative event in “T-cell acute lymphoblastic leukemia” (T-ALL). “Myeloid-derived suppressor cells” (MDSCs) inhibit host immune responses in the tumor environment, favoring cancer...

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Principais autores: Paola Grazioli, Andrea Orlando, Nike Giordano, Claudia Noce, Giovanna Peruzzi, Behnaz Abdollahzadeh, Isabella Screpanti, Antonio Francesco Campese
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-04-01
Serier:Frontiers in Immunology
Fag:
MDSC
T-ALL
Notch
IL-6
tumor microenvironment
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2022.809261/full
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