Notch-Signaling Deregulation Induces Myeloid-Derived Suppressor Cells in T-Cell Acute Lymphoblastic Leukemia

Notch receptors deeply influence T-cell development and differentiation, and their dysregulation represents a frequent causative event in “T-cell acute lymphoblastic leukemia” (T-ALL). “Myeloid-derived suppressor cells” (MDSCs) inhibit host immune responses in the tumor environment, favoring cancer...

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Principais autores:	Paola Grazioli, Andrea Orlando, Nike Giordano, Claudia Noce, Giovanna Peruzzi, Behnaz Abdollahzadeh, Isabella Screpanti, Antonio Francesco Campese
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2022-04-01
Series:	Frontiers in Immunology
Assuntos:	MDSC T-ALL Notch IL-6 tumor microenvironment
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.809261/full
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