Comprehensive comparison of enzymatic and bisulfite DNA methylation analysis in clinically relevant samples

Abstract Background Bisulfite conversion is considered the gold standard for DNA methylation analysis, but it damages DNA and performs sub-optimally with clinical samples (e.g., formalin-fixed paraffin-embedded and circulating free plasma DNA (cfDNA)). Here we describe a comprehensive comparison of...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Barrett Nuttall, Daniel L. Karl, Kathleen Burke, Megan Callahan, Kerrin Mendler, Pablo Cingolani, Steven Criscione, Serhiy Naumenko, Elena Bibikova, Veerendra Munugalavadla, John C. Byrd, Richard R. Furman, Jennifer R. Brown, Andrew Mortlock, Brian A. Dougherty, J. Carl Barrett, Maurizio Scaltriti, James Hadfield
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-10-01
Serie:	Clinical Epigenetics
Soggetti:	Methylation Enzymatic methylation sequencing Bisulfite sequencing Targeted methylation sequencing Chronic lymphocytic leukemia
Accesso online:	https://doi.org/10.1186/s13148-025-01959-0
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!