Comprehensive comparison of enzymatic and bisulfite DNA methylation analysis in clinically relevant samples

Abstract Background Bisulfite conversion is considered the gold standard for DNA methylation analysis, but it damages DNA and performs sub-optimally with clinical samples (e.g., formalin-fixed paraffin-embedded and circulating free plasma DNA (cfDNA)). Here we describe a comprehensive comparison of...

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Autors principals:	Barrett Nuttall, Daniel L. Karl, Kathleen Burke, Megan Callahan, Kerrin Mendler, Pablo Cingolani, Steven Criscione, Serhiy Naumenko, Elena Bibikova, Veerendra Munugalavadla, John C. Byrd, Richard R. Furman, Jennifer R. Brown, Andrew Mortlock, Brian A. Dougherty, J. Carl Barrett, Maurizio Scaltriti, James Hadfield
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-10-01
Col·lecció:	Clinical Epigenetics
Matèries:	Methylation Enzymatic methylation sequencing Bisulfite sequencing Targeted methylation sequencing Chronic lymphocytic leukemia
Accés en línia:	https://doi.org/10.1186/s13148-025-01959-0
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